Methyl 4-(4-piperidyl)benzoate hydrochloride
[CAS 936130-82-4]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Salt of carboxylic acid ester and its derivatives
• Name: Methyl 4-(4-piperidyl)benzoate hydrochloride
• Synonyms: 4-(4-Methoxycarbonylphenyl)piperidine hydrochloride
• Molecular Formula: C₁₃H₁₇NO₂.HCl
• Molecular Weight: 255.74
• CAS Registry Number: 936130-82-4
• EC Number: 847-225-8
• SMILES: COC(=O)C1=CC=C(C=C1)C2CCNCC2.Cl

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2A	H319

chemBlink Chemical Story

Methyl 4-(4-piperidyl)benzoate hydrochloride is the hydrochloride salt of methyl 4-(piperidin-4-yl)benzoate. The corresponding free base appeared in the preceding chemBlink batch as CAS 281235-04-9, making the pair a clear example of why registry identity matters. Protonating the piperidine nitrogen with hydrochloric acid produces a defined ionic salt without changing the carbon skeleton. Salt formation can change crystallinity, solubility, handling, and analytical behavior, so free base and hydrochloride should not be treated as interchangeable records. The piperidine nitrogen can be further derivatized, while the methyl benzoate can be hydrolyzed or converted to other carboxylic-acid derivatives. Public information supports a pharmaceutical/research-intermediate role rather than an independent therapeutic use.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

Practical behavior emerges from the complete molecular and material system. Structure, physical form, reaction conditions, manufacturing route, and surrounding environment can all affect performance. Connecting these details to a documented synthetic, industrial, analytical, or biological role is what turns a registry entry into a meaningful chemical story.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

References:
1. Specialist catalogs. CAS 936130-82-4 and CAS 281235-04-9.
2. Pharmaceutical chemistry references on free-base/salt properties.

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