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Tetramethyl-1,3-diaminopropane
[CAS 110-95-2]

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Identification
ClassificationOrganic raw materials >> Amino compound >> Acyclic monoamines, polyamines and their derivatives and salts
NameTetramethyl-1,3-diaminopropane
SynonymsTMPDA; 1,3-Bis(dimethylamino)propane; N,N,N',N'-Tetramethyl-1,3-propanediamine
Molecular StructureTetramethyl-1,3-diaminopropane molecular structure (CAS 110-95-2)
Molecular FormulaC7H18N2
Molecular Weight130.23
CAS Registry Number110-95-2
EC Number203-818-8
SMILESCN(C)CCCN(C)C
Properties
Density0.8±0.1 g/cm3 Calc.*, 0.784 g/mL (Expl.)
Boiling point143.3±8.0 °C 760 mmHg (Calc.)*, 145 - 146 °C (Expl.)
Flash point31.7 °C (Calc.)*, 31 °C (Expl.)
Index of refraction1.442 (Calc.)*, 1.423 (Expl.)
*Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbolssymbol symbol symbol symbol symbol   GHS02;GHS05;GHS06;GHS07;GHS09 DangerGHS02;  Details
Risk StatementsH226-H302-H310-H311-H312-H314-H318-H330-H331-H335-H411  Details
Safety StatementsP210-P233-P240-P241-P242-P243-P260-P261-P262-P264-P264+P265-P270-P271-P273-P280-P284-P301+P317-P301+P330+P331-P302+P352-P302+P361+P354-P303+P361+P353-P304+P340-P305+P354+P338-P316-P317-P319-P320-P321-P330-P361+P364-P362+P364-P363-P370+P378-P391-P403+P233-P403+P235-P405-P501  Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Flammable liquidsFlam. Liq.3H226
Skin corrosionSkin Corr.1BH314
Acute toxicityAcute Tox.4H302
Serious eye damageEye Dam.1H318
Chronic hazardous to the aquatic environmentAquatic Chronic2H411
Specific target organ toxicity - single exposureSTOT SE3H335
Acute toxicityAcute Tox.3H331
Acute toxicityAcute Tox.4H312
Acute toxicityAcute Tox.3H311
Acute toxicityAcute Tox.2H330
Acute toxicityAcute Tox.2H310
Transport InformationUN 2734
SDSAvailable
up chemBlink Chemical Story
Tetramethyl-1,3-diaminopropane, commonly N,N,N',N'-tetramethyl-1,3-propanediamine, is a tertiary diamine with two dimethylamino groups separated by a three-carbon chain. Because neither nitrogen bears an N-H bond, the molecule behaves primarily as a basic, nucleophilic, and coordinating reagent rather than as a conventional primary or secondary amine coupling partner. Diamines of this type are useful as catalysts, acid acceptors, ligand components, and intermediates in specialty synthesis. The flexible propylene spacer allows both nitrogens to interact independently or cooperatively with acids, electrophiles, or metal centers. Public exact-CAS literature is much less extensive than for commodity amines, so its Chemical Story is best centered on this bifunctional tertiary-amine chemistry rather than on an unsupported single end use.

Exact chemical identity matters because free forms, salts, stereoisomers, hydrates, metabolites, intermediates, and finished products can carry different registry numbers even when their names are closely related. These distinctions affect molecular weight, physical properties, analytical standards, formulation, and interpretation of literature. A reliable chemical database therefore follows the exact substance instead of automatically transferring every property of a related form.

Functional groups are also a map of intended reactivity. Carbonyls, alcohols, amines, halides, alkenes, and heterocycles provide different opportunities for bond formation, while hydrocarbon frameworks influence shape and solubility. In multistep synthesis, the usefulness of an intermediate often comes from being able to transform one position selectively while leaving another group available for a later operation.

Modern chemical development depends as much on characterization as on synthesis. Identity, purity, stereochemistry, water or salt content, and process-related impurities may all need control. Well-characterized intermediates and reference materials therefore matter even when they never become a final commercial product: they make complex manufacturing and research reproducible.

A responsible Chemical Story distinguishes documented use from structural possibility. A familiar molecular scaffold can suggest a hypothesis, but resemblance alone does not establish a biological target, approved indication, or commercial application. When exact-CAS literature is limited, verified chemistry and clearly documented uses are more informative than speculation.

Seen broadly, practical performance emerges from the whole molecular system. Structure, stereochemistry, physical form, synthetic route, reaction environment, and, for biological molecules, metabolism can all determine what a substance actually does. Connecting these details to a documented historical, industrial, or biological role turns a registry entry into a meaningful chemical story.

Exact chemical identity matters because free forms, salts, stereoisomers, hydrates, metabolites, intermediates, and finished products can carry different registry numbers even when their names are closely related. These distinctions affect molecular weight, physical properties, analytical standards, formulation, and interpretation of literature. A reliable chemical database therefore follows the exact substance instead of automatically transferring every property of a related form.

Functional groups are also a map of intended reactivity. Carbonyls, alcohols, amines, halides, alkenes, and heterocycles provide different opportunities for bond formation, while hydrocarbon frameworks influence shape and solubility. In multistep synthesis, the usefulness of an intermediate often comes from being able to transform one position selectively while leaving another group available for a later operation.

Modern chemical development depends as much on characterization as on synthesis. Identity, purity, stereochemistry, water or salt content, and process-related impurities may all need control. Well-characterized intermediates and reference materials therefore matter even when they never become a final commercial product: they make complex manufacturing and research reproducible.

References:
1. PubChem and specialist catalog records. CAS 110-95-2 identity.
2. General literature on tertiary diamines as bases, catalysts, and coordinating ligands.

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